Cover of Genome Guardian

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Games like Genome Guardian

2024PCNintendo SwitchSteam Deck playable92 % positive11.99 €

A top-down roguelite shooter set at the microscopic level, where you fend off hostile aliens with combinable turrets, perks and power-ups. The appeal lies in experimenting with many weapon combinations across quick runs.

Runs that play out differently every time
Shooting and gunplay
Strong character progression
Sci-fi setting

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More in these topics: Roguelikes and roguelites Action games Hidden gems Indie games

The closest matches for Genome Guardian are Starward Rogue, Deep Rock Galactic: Survivor and Beat Invaders. Each of these 10 games shares something of what makes Genome Guardian special – the reasons are listed right on each game.

Best match

Starward Rogue

97 %Match

2016PCPlayStationXboxNintendo SwitchSteam Deck playable89 % positive11.79 €

Runs that play out differently every time
Shooting and gunplay
Sci-fi setting

A roguelite bullet-hell shooter where you fight through randomly generated labyrinths inside a star, weaving through waves of projectiles while collecting weapons and upgrades. Each run feels different thanks to varied item combinations.

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Deep Rock Galactic: Survivor

Strong character progression

A survivor-like set in the Deep Rock universe where a lone dwarf auto-shoots through alien swarms while carving through destructible rock for minerals. Synergizing weapon upgrades and persistent unlocks deliver that one-more-run pull.

Beat Invaders

Runs that play out differently every time

A fast space shoot-'em-up where you blast through enemy fleets, upgrade your ship with rockets and armor, and take down a final boss. Neon visuals and music-driven action give it a strong rhythm.

Void Scrappers

Runs that play out differently every time

A fast arcade space shooter with roguelike runs: you blast alien swarms, collect scrap to power up your ship mid-run, and unlock new pilots and weapons between attempts.

Go Mecha Ball

Runs that play out differently every time

A fast arcade roguelite shooter where you play a rolling mech ball, shooting and boosting through a colorful futuristic world. Increasingly outlandish weapons and upgrades let you remix your build every run.

Galak-Z: The Dimensional

Runs that play out differently every time

A punchy 2D space shooter with physics-driven flight, roguelike structure and a look inspired by 80s mecha anime. Intense dogfights demand quick reflexes and smart resource management.

Deadlink

Runs that play out differently every time

A fast cyberpunk first-person shooter with roguelite structure where you pilot a remote combat shell through corporate strongholds. Fluid movement, destructible environments and upgrades between runs drive the pace and replayability.

Galactic Glitch

Runs that play out differently every time

A roguelike shooter built around physics: hurl rocks, catch missiles and turn torn-apart enemies into ammo. You craft your own build from many weapons and powers while exploring a simulated universe.

Brotato

Strong character progression

A snappy arena roguelite where a potato wields up to six weapons at once against waves of aliens. Short runs plus dozens of quirky characters and item synergies make for huge replay value.

Roboquest

Runs that play out differently every time

A fast, colorful roguelite FPS where you play a rebooted robot Guardian and blast hordes of machines through shifting levels, solo or in co-op. Fluid movement, varied weapons and classes make every run feel different.

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